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Post 60

Monday, February 2, 2009 - 7:20amSanction this postReply
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Bill,

The doctors who tell folks to take calcium for cramps -- while ignoring magnesium -- are wrong. Instead, a good magnesium-calcium ratio to try for cramps is about 1:1 -- i.e., a milligram of magnesium for every milligram of calcium ingested.

Having a 1:1 ratio makes sense in light of evolution. Our distant ancestors carried the human genome through 100s and 100s of thousands of years of natural selection with roughly-equivalent intakes of calcium and magnesium. If over 90% of the time during the evolution of your genome your ancestors ate much differently than you, then it's risky to not try to copy their diet as much as you can. As you know, there are a lot of risk-takers out there.

:-)

What about calcified arteries being promoted by too much calcium? I read a recent study which said that hardening of the arteries was worse in women who took a lot of calcium to prevent osteoporosis. What's your take on that? I also read something recently about vitamin K helping to reverse arterial calcification.
Answers are coming ...

Ed

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Post 61

Monday, February 2, 2009 - 8:09amSanction this postReply
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damn it, ed! Stop making sense. I'm not sure if I'm capable of blanking out enough to convince myself my ancestors had high intakes of diet dr. pepper.

Post 62

Monday, February 2, 2009 - 8:22amSanction this postReply
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Bill,

What about calcified arteries being promoted by too much calcium? I read a recent study which said that hardening of the arteries was worse in women who took a lot of calcium to prevent osteoporosis. What's your take on that? I also read something recently about vitamin K helping to reverse arterial calcification.
If taking a lot of calcium promotes any arterial calcification, then it's effect is minor and offset by other, more-major things. Some calcium intake is actually indicated in arterial calcification due to excessive blood phosphate. I've identified nine, potentially-major players in arterial calcification:

(1) vitamin K (as you said)
(2) phosphate
(3) insulin resistance
(4) inflammation
(5) long-term antibiotic use (anti-menaquinone)
(6) warfarin use (anti-vitamin K)
(7) kidney failure
(8) statin use (rhabdomyolytic hyperphosphatemia) [?]
(9) vitamin D [?]

The last two are questionable. For statins, we'd need to validate rhabdomyolysis (muscle cell breakdown). After validating rhabdomyolysis, we'd need to verify that it's enough to cause hyperphosphatemia. After that, we've got a true culprit in arterial calcification. For vitamin D, too little of it can be as bad (or worse?) than too much of it. Perhaps more important is to control inflammation, which activates vitamin D at the arterial site.

Caveat: I'm not a doctor, just a genius. Work with your healthcare professional when altering your prescriptions, diet or lifestyle.

:-)

Ed


Reference:

At www.ncbi.nlm.nih.gov/pubmed, search for:

11706300

15786402

17606264

17765144

17374084

18433704

18841280

18562594

19179058

3060161

(Edited by Ed Thompson on 2/02, 8:26am)


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