I very much like this painting. Weightlessness definitely allows for a different composition than in a regular old Earth-bound scene. There is a sense of freedom and accomplishment in this painting, but this is interesting because it's a painting of the future with the title "How Far We've Come." So it seems very optimistic in that it's showing someone in the future looking back at all that has been (or will be to us) accomplished.
I think the contrast between the inside of the space station and the shuttle outside gives the painting a further strong sense of optimism. The shuttle outside ("Aristotle") is a Columbia-class shuttle, so this scene must be in the somewhat near future, but the spaciousness and large glass of the space station is far more advanced than anything we could cobble today.