| | Jon, no.
The difference has to do with something more than intellect. A criminal can be awful cunning -- but lacks the character to live well. Built character comes from habitual action (Aristotle). There is no replacement -- no dispensation -- from that fact of reality.
You can be cunning, and you can be moral -- but these 2 things don't 'necessarily' coincide. By the way, here are some other molecules that can 'change who you are' (ie. that can make you smarter than you are right now) ...
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The effect of vincamine, hydergine and piracetam on the firing rate of locus coeruleus neurons. J Neural Transm. 1982;55(2):101-9.
All three compounds, when administered intraperitoneally, increased the firing rate of noradrenergic neurons in the chloral hydrate anaesthetized animals. Vincamine and hydergine had a similar potency producing a maximal mean increase of about 70% at a dose of 1 mg/kg.
Likewise, piracetam was significantly less potent eliciting a 30 to 40% increase in firing at doses of 300 and 1000 mg/kg, respectively.
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[On the meaning of psychometrically operationalized therapeutic effects in the treatment of brain insufficiency phenomena caused by old age demonstrated by the "Nurnberger-Alters-Inventar" (author's transl)] Arzneimittelforschung. 1982;32(5):584-90.
The drug effects of dihydroergotoxine (Hydergin) and piracetam were examined in a sample of 44 old-age home residents, 76 years average age, using performance tests, nurse-ratings for the need of care and self-evaluation measures of the "Nurnberger Alters-Inventar" (NAI).
Within a subsample of 18 patients, selected according to certain EEG-criteria, EEG day profiles were assessed. The medication lasted for 6 weeks. 2 mg dihydroergotoxine or 0.8 g piracetam, respectively, were applied three times a day.
Initial effects were observed for both medications after 3 weeks in terms of improvements in the cognitive performance, for the activities of daily living and need of care, respectively, and for subjective, physical, functional and social self-evaluations.
After 6 weeks, at the end of the study, these effects were confirmed only for dihydroergotoxine, whereas the piracetam subjects could not stabilize these improvements. The psychometric results were corroberated by the EEG-data.
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The impairment of long-term potentiation in rats with medial septal lesion and its restoration by cognition enhancers. Neurobiology (Bp). 1994;2(3):255-66.
The effect of medial septal lesion on long-term potentiation (LTP) and the action of four cognition enhancers were studied in rat dentate gyrus, in vivo.
The medial septum was partially lesioned by a radiofrequency lesion generator. The effect of lesion was studied on hippocampal function measuring two parameters; the amplitude of the maximal population spikes and the increase in population spikes evoked by high frequency stimulation of the perforant path (LTP).
Both parameters were found to be significantly lower in the lesioned group than in the non-lesioned one. Four drugs (physostigmine, piracetam, vinpocetine and Hydergine), known to be effective in dementia and/or in cognitive impairments, were administered 1 h after the lesion procedure and thereafter once a day for 6 days after the operation.
LTP was induced and measured at day 7. All drugs produced a complete restoration of the measured parameters affected by the lesion.
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