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Post 20

Monday, March 10, 2008 - 6:56pmSanction this postReply
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They all are. Here is the link ...

http://www.thepaleodiet.com/published_research/

Ed


Post 21

Monday, March 10, 2008 - 9:52pmSanction this postReply
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Hey Ed,

Glad to see some in-depth research on that site.  That'll keep me busy for some time.  From the look of the home page it looks just like a Raw Foods or Atkin's promotion, which honestly turned me off immediately.

I've noticed that you frequently pull abstracts out for our enjoyment.  Do you get most of them from anywhere in particular?  Hopefully without subscription?  http://www.ncbi.nlm.nih.gov/ is the best source I'm aware of.  Occasionally it offers entire articles for free.

(if the following topic is well covered in the abstracts listed, let me know) I noticed your list is alcohol free.  I am under the impression that alcohol is one tremendously researched health topic and hundred's of studies confirm that the alcohol itself has health potential (confounding factors looked into. and of course all studies had an average limit of 2 a day for men, half that for women).  Wines, of course, have a health potential beyond their alcoholic content, so I'm glad to see that you chose alcohol-free wines over sugar loaded, skinless-grape juice.

I appreciate your response to the coffee question, that would have been my next.

Much thanks, Ed.


Post 22

Monday, March 10, 2008 - 10:24pmSanction this postReply
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Doug, yes, I get most of my stuff from NCBI (the very place that you linked to).

Booze
While researching for a paper I'm writing (I'm a college boy), I ran across a recent study showing men getting good results with 2-4 drink-equivalents a day, and the ladies hamming it up with 1-2 a day. That's the highest level of ETOH intake that I've ever seen get a rubber stamp of approval.

;-)

Ed


Post 23

Monday, March 10, 2008 - 10:58pmSanction this postReply
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Ed,

While I appreciate your scholarly references, you act as if we have to read them all, before you'll consider anything we have to say. I did read a couple of them, and made a comment in my last post. You just blew it off. This is, if I may say, condescending. The articles you listed do require some time to read, after all. And I did in good faith look them up and read some of them. But at this point, your attitude has dampened my enthusiasm. I can't say that I'm inclined to continue the discussion.

- Bill

Post 24

Tuesday, March 11, 2008 - 12:36amSanction this postReply
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Bill,

I do not apologize for being short with you regarding this matter. I think I made a good case about the morality of continued engagement in post 18. I admit that I'm holding somewhat of a double standard here, with you and Bob. Ironically, it's because I respect your intellects (though Bob may not admit that he is in possession of an intellect, because intellects are immaterial things).

;-)

With other types of folks, I'd go around and go around -- revealing to 3rd party readers just how ignorant or arrogant the other guy is. Indeed, in my half decade of contribution here, I performed this altruistic task with the likes of G. Stolyarov II, Daniel Barnes, Nick Otani, and the late Nathan Hawking (among several, several others).

Call me tired or full of expectations, but I'd rather have a more mutually-informed kind of a discussion with you (and Bob). You could take that as a compliment, though you might only be able to view it as a backhanded one, nonetheless. Your words have touched me, however, and I now have a change of heart and a willed extension of generosity. Please, allow me to answer your earlier inquiries ...

In Post #6, you recommend consuming saturated fats at less than 10% of total energy, but from one of the articles you cited, the author says that the paleolithic hunter-gathers consumed saturated fats between 10% and 13% of total energy.
Please take what I wrote in post 6 more literally (I meant it more literally than your quote implies). What I wrote there was a summary of points from an article -- rather than a recommendation. This might appear like rhetoricized semantics, but the subtle point here really does make a difference. Now that I've established that I wasn't recommending anything in post 6 (except maybe for folks to retrieve a copy of the article and scour it), it's easier to evaluate it for things like consistency.

It turns out that saturated fats formed roughly 7-13% of total energy in really old diets so, you're correct that I was incorrect -- just not correct that it matters (because I wasn't giving a recommendation; which is when summaries can be seen as morally deficient when they're incomplete or otherwise imperfect). In short, your ability to find a discrepancy, while laudable, doesn't damage the picture of old food. If you want me to personally take a stand and recommend a level for saturated fat, fine: 7-13%.

;-)
Also, you can correct me if I am wrong, but you seem to be arguing that because our remote ancestors ate a certain way, it follows that we should eat that way. Why? Because we evolved on such a diet? But the fact that we evolved on it does not mean that every component of it is necessarily consistent with optimal health and longevity.
I am arguing what you say I'm arguing (in spirit if not in letter). The logic is to get the environment that human genes thrive in -- though I understand your fine point about how Natural Selection only "focuses" on getting members of a species to reproductive age. If you read more about the science, particularly the last reference about consideration of counterarguments, then you would find that there is a "consilience" going on here -- instead of merely one line of reasoning pointing to why we should eat certain things. For a refresher, here's what Whewell meant by consilience ...

Whewell called this type of evidence a “jumping together” or “consilience” of inductions. An induction, which results from the colligation of one class of facts, is found also to colligate successfully facts belonging to another class. Whewell's notion of consilience is thus related to his view of natural classes of objects or events.

To understand this confirmation criterion, it may be helpful to schematize the “jumping together” that occurred in the case of Newton's law of universal gravitation, Whewell's exemplary case of consilience. On Whewell's view, Newton used the form of inference Whewell characterized as “discoverers' induction” in order to reach his universal gravitation law, the inverse-square law of attraction. Part of this process is portrayed in book III of the Principia, where Newton listed a number of “propositions.” These propositions are empirical laws that are inferred from certain “phenomena” (which are described in the preceding section of book III).

The first such proposition or law is that “the forces by which the circumjovial planets are continually drawn off from rectilinear motions, and retained in their proper orbits, tend to Jupiter's centre; and are inversely as the squares of the distances of the places of those planets from that centre.” The result of another, separate induction from the phenomena of “planetary motion” is that “the forces by which the primary planets are continually drawn off from rectilinear motions, and retained in their proper orbits, tend to the sun; and are inversely as the squares of the distances of the places of those planets from the sun's centre.”

Newton saw that these laws, as well as other results of a number of different inductions, coincided in postulating the existence of an inverse-square attractive force as the cause of various classes of phenomena. According to Whewell, Newton saw that these inductions “leap to the same point;” i.e., to the same law. Newton was then able to bring together inductively (or “colligate”) these laws, and facts of other kinds of events (e.g., the class of events known as “falling bodies”), into a new, more general law, namely the universal gravitation law ...-Stanford Encyclopedia of Philosophy online
So, though your point stands that Natural Selection only "cared" about reproductive success -- which can, at least "logically", be something different than optimal health and human longevity -- the fact that old food is good is repeatedly shown to be so under different lines of reasoning (such as the drop in body height and bone density; after the adoption of grains as a staple food).

 
We are able to live and reproduce quite satisfactorily on the standard American diet, which as you know is not the best diet for us. Does that mean that our descendants living millennia from now should adhere to such a diet? No? Then why does it follow, based on your evolutionary rationale, that the best diet for human beings living today is a hunter-gatherer diet?
There may come a time when processed food becomes healthy for humans, but the genetic code will have to change a lot first -- it'll be a REALLY long time before Hostess Twinkies are healthy for existing humans anywhere on Earth. If mutation allowed for us to make more vitamins from scratch, and to deal better with refined carbohydrate and trans fats, THEN we could live well on Twinkies -- but not UNTIL then will we ever be able to live on Twinkies.

The fact that our remote ancestors survived and reproduced on that diet does not mean that we should follow it -- at least not in all of its particulars. We should follow a diet that gives us optimal health and longevity, even if our remote ancestors didn't follow it.
Agreed. Again, if you read the Consideration of CounterArguments article, you will find similar reasoning outlined (that the Evolutionary Hypothesis, if it is to be ultimately disproven, must be disproven by experiment and nothing less than that).

Ed


Post 25

Tuesday, March 11, 2008 - 1:44amSanction this postReply
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In the Psalms it says "Wine gladdens the heart of man". A moderate dose of red wine can actually clean out the coronary arteries a bit.

Bob Kolker

(Edited by Robert J. Kolker on 3/11, 1:45am)


Post 26

Tuesday, March 11, 2008 - 4:03amSanction this postReply
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Bob,

That's only analogically correct. What red wine actually does is provide polyphenolics. What red wine polyphenols -- and berry polyphenols -- do is act as a blood thinner, vasodilator, and plasma antioxidant. It's for these 3 reasons that red wine -- or berries -- "gladdens the heart of man."


Ed


Reference:

Protective effect of resveratrol, a red wine constituent polyphenol, on rats subjected to portal vein thrombosis. Transplant Proc. 2008 Jan-Feb;40(1):290-2.

Relaxation induced by red wine polyphenolic compounds in rat pulmonary arteries: lack of inhibition by NO-synthase inhibitor. Fundam Clin Pharmacol. 2008 Feb;22(1):25-35.

The increase in human plasma antioxidant capacity after red wine consumption is due to both plasma urate and wine polyphenols. Atherosclerosis. 2008 Mar;197(1):250-6.



Post 27

Tuesday, March 11, 2008 - 12:11pmSanction this postReply
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Bill,

"Strong people are harder to kill than weak people, and more useful in general." -Mark Rippetoe
 
Mark Rippetoe is the author of "Starting Strength".  A great book for people trying to get strong.


Post 28

Tuesday, March 11, 2008 - 7:41pmSanction this postReply
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Thanks, Mike.

I'll check it out. Remember I'm 68, so I have to be a bit careful to avoid injuring myself, if I embark on a weight training program. I know you're 59, but there's a big difference between 59 and 68. Trust me! Also, I suspect that you were in better muscular condition than I when you started your program.

- Bill

Post 29

Wednesday, March 12, 2008 - 11:30amSanction this postReply
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Ed,

Thanks for your reply. You wrote,
So, though your point stands that Natural Selection only "cared" about reproductive success -- which can, at least "logically", be something different than optimal health and human longevity -- the fact that old food is good is repeatedly shown to be so under different lines of reasoning (such as the drop in body height and bone density; after the adoption of grains as a staple food).
The Masai of Africa, who survive on a diet of mostly milk and blood, which they get from their cattle, are very tall due to the high protein and vitamin B12 content of their diet, but they exhibit atherosclerosis to a greater degree than the average American. They don’t die of heart attacks as we do, because their coronary arteries are wider than ours, due to all the exercise they get from their cattle herding. Body height does not automatically imply a superior diet.

It is true that a diet very light in protein, such as a macrobiotic diet, can result in reduced bone density, but diets very high in protein can also cause thinner bones. The Eskimos have a very high-protein diet and more osteoporosis than the average American, because their diet is sorely lacking in fruits and vegetables. What’s important for bone mineral density is not so much whether the diet is grain-based or meat based, but whether or not it contains enough (but not too much) protein and sufficient fruits and vegetables to balance out the other acid-forming components of the diet. It should be noted here that the sulfur-containing amino acids, which predominate in animal protein, have a more calcium draining effect on the bones than do vegetable proteins. In any case, the point is that a diet that increases bone density may not be ideal in other respects. You can’t automatically conclude that because one diet results in greater height and bone density than another, it is therefore optimal, any more than you can conclude that because our forebears ate a certain way, we should therefore eat that way.

Another problem with high-protein diets is that they can be hard on the kidneys. The Nurses’ Health Study showed that women with mildly decreased kidney function (estimated GFR (glomerular filtration rate) between 55 and 80 ml/min per 1.73 m2) had a 3.5-fold increased risk for losing kidney function when protein intake was in the highest (90 g/d) versus lowest (60 g/d) quintile. Importantly, the increased risk of dietary protein was confined to intake of animal meats. Vegetable or dairy-based protein sources did not adversely affect kidney function. A Dutch study of 680 white individuals between the ages of 50 and 75 yr found that each 0.1-g/kg per d increment of dietary protein intake was associated with a 20% increased risk for microalbuminuria after adjustment for age, gender, and traditional cardiovascular risk factors.

I wrote, “We are able to live and reproduce quite satisfactorily on the standard American diet, which as you know is not the best diet for us. Does that mean that our descendants living millennia from now should adhere to such a diet? No? Then why does it follow, based on your evolutionary rationale, that the best diet for human beings living today is a hunter-gatherer diet?”
There may come a time when processed food becomes healthy for humans, but the genetic code will have to change a lot first -- it'll be a REALLY long time before Hostess Twinkies are healthy for existing humans anywhere on Earth. If mutation allowed for us to make more vitamins from scratch, and to deal better with refined carbohydrate and trans fats, THEN we could live well on Twinkies -- but not UNTIL then will we ever be able to live on Twinkies.
Ed, did you really think that I was advocating Hostess Twinkies as an alternative to the diet you’re recommending? To say that the diet our forebears consumed is not necessarily optimal is not to say that Hostess Twinkies and other forms of junk food are. If ever there was a non-sequitur, that certainly is!

I wrote, “The fact that our remote ancestors survived and reproduced on that diet does not mean that we should follow it -- at least not in all of its particulars. We should follow a diet that gives us optimal health and longevity, even if our remote ancestors didn't follow it.”
Agreed. Again, if you read the Consideration of CounterArguments article, you will find similar reasoning outlined (that the Evolutionary Hypothesis, if it is to be ultimately disproven, must be disproven by experiment and nothing less than that).
But if you agree with me, than why do you use the argument that because we evolved on such a diet, it is therefore optimal?

By the way, I see in the latest issue of Life Extension magazine that “Foods in the fat and meat (protein) groups contain thirty-fold and twelve-fold higher AGE content (advanced glycation end products) respectively, than foods in the carbohydrate group. On the other hand, fresh fruits, vegetables, whole grains, raw nuts, and other unprocessed, unrefined foods have low levels of glycotoxins.” Of course, nuts contain a lot of fat too, so go light on the nuts.

- Bill


(Edited by William Dwyer on 3/12, 2:21pm)


Post 30

Wednesday, March 12, 2008 - 6:53pmSanction this postReply
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Bill,

========
The Masai of Africa, who survive on a diet of mostly milk and blood, which they get from their cattle, are very tall due to the high protein and vitamin B12 content of their diet, but they exhibit atherosclerosis to a greater degree than the average American. They don’t die of heart attacks as we do, because their coronary arteries are wider than ours, due to all the exercise they get from their cattle herding.
========

The reason why their coronary arteries are wider than ours is because they have more atherosclerosis. When arteries build up with plaque, then they narrow on the inside (stenosis) -- but the whole artery gets bigger so that blood will still flow in spite of stenosis. Plaque build-up never stops blood flow (you'll never see an artery with 100% stenosis -- though 95% is possible).

The real reason that the Masai aren't harmed from a high intake of saturated fat is because a high intake of saturated fat isn't -- inherently -- harmful to humans. More than a dozen studies of high-fat diets have verified or validated this fact of reality (references available upon request).

Here's a telling (though unconventional) review of this ...

========
The questionable role of saturated and polyunsaturated fatty acids in cardiovascular disease. J Clin Epidemiol. 1998 Jun;51(6):443-60.

" ... The positive ecological correlations between national intakes of total fat (TF) and SFA and cardiovascular mortality found in earlier studies were absent or negative in the larger, more recent studies. Secular trends of national fat consumption and mortality from coronary heart disease (CHD) in 18-35 countries (four studies) during different time periods diverged from each other as often as they coincided. ...

... In three of four cohort studies of atherosclerosis, the vascular changes were unassociated with SFA or PUFA; in one study they were inversely related to TF. No significant differences in fat intake were noted in six case-control studies of CVD patients and CVD-free controls; and neither total or CHD mortality were lowered in a meta-analysis of nine controlled, randomized dietary trials with substantial reductions of dietary fats, in six trials combined with addition of PUFA. ...
========

I'll respond to the other points in following posts ...

Ed

Post 31

Wednesday, March 12, 2008 - 7:39pmSanction this postReply
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I don't know what the ultimate objective of your diet is here, but no diet performs as well as, in every testable health aspect, a moderate caloric restriction with optimal nutrition diet does. Consume 5 - 10% fewer calories than your RDA, and get at or more than your RDA of nutrients, and you'll live longer, have lower cholesterol and blood pressure, have a lower chance of developing cancer, and if you do, can expect it to progress much slower, than any other diet yet known, it is also one of the most empirically tested diets and has been tested and proven to increase the *real* maximum potential life span of every animal it has been tested on, from water fleas to primates.

Of course, it's a bitch to stick to.

Post 32

Wednesday, March 12, 2008 - 8:59pmSanction this postReply
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Michael,

What you are describing is called calorie restriction or CR. It usually requires a difficult 30% reduction (rather than 5-10%), and it's benefits might be achieved easier by carbohydrate reduction alone.

References upon request.

Ed

Post 33

Thursday, March 13, 2008 - 12:51amSanction this postReply
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I wrote, "The Masai of Africa, who survive on a diet of mostly milk and blood, which they get from their cattle, are very tall due to the high protein and vitamin B12 content of their diet, but they exhibit atherosclerosis to a greater degree than the average American. They don’t die of heart attacks as we do, because their coronary arteries are wider than ours, due to all the exercise they get from their cattle herding."

Ed replied,
The reason why their coronary arteries are wider than ours is because they have more atherosclerosis. When arteries build up with plaque, then they narrow on the inside (stenosis) -- but the whole artery gets bigger so that blood will still flow in spite of stenosis. Plaque build-up never stops blood flow (you'll never see an artery with 100% stenosis -- though 95% is possible).
If what you're saying is true, then why do the Masai not have angina or heart attacks like Americans? Why does the buildup of plaque narrow the arteries of Americans, greatly reducing blood flow to their hearts and forming blood clots that partially or totally block their coronary arteries, when this sort of thing doesn't happen to the Masai? Why do Americans get heart attacks from atherosclerosis, when the Masai do not? If it is atherosclerosis that is causing the widened arteries, shouldn't the arteries of Americans widen to protect them from narrowed blood flow and attacks of angina in the same way that it protects the Masai?

In fact, the arteries of the Masai are twice the size of Americans', while the degree of their atherosclerosis is only slightly higher. The reason their coronary arteries are so much wider is that from an early age, they put in 10 to 20 miles a day walking their cattle.
The real reason that the Masai aren't harmed from a high intake of saturated fat is because a high intake of saturated fat isn't -- inherently -- harmful to humans. More than a dozen studies of high-fat diets have verified or validated this fact of reality (references available upon request).
So, you're saying that extensive atherosclerosis and the narrowing of the coronary arteries isn't due in most cases to a high-saturated fat intake? Wow, that certainly goes against the conventional wisdom, and against the epidemiological studies I'm familiar with.
Here's a telling (though unconventional) review of this ...

========
The questionable role of saturated and polyunsaturated fatty acids in cardiovascular disease. J Clin Epidemiol. 1998 Jun;51(6):443-60.

" ... The positive ecological correlations between national intakes of total fat (TF) and SFA and cardiovascular mortality found in earlier studies were absent or negative in the larger, more recent studies. Secular trends of national fat consumption and mortality from coronary heart disease (CHD) in 18-35 countries (four studies) during different time periods diverged from each other as often as they coincided. ...

... In three of four cohort studies of atherosclerosis, the vascular changes were unassociated with SFA or PUFA; in one study they were inversely related to TF. No significant differences in fat intake were noted in six case-control studies of CVD patients and CVD-free controls; and neither total or CHD mortality were lowered in a meta-analysis of nine controlled, randomized dietary trials with substantial reductions of dietary fats, in six trials combined with addition of PUFA. ...
========
The question I would ask is, what diets are they comparing? because very low fat diets (with 10% of total calories as fat) in indigenous populations like the Indians of Northern Mexico and certain African tribes indicate zero heart disease and correlate with very low total serum cholesterol between 110 and 130 mg/dL, while rampant heart disease in Western first-world countries is correlated with diets that are much higher in fat. I'd say that's pretty good evidence for the conventional view.

Of course, if you're comparing a diet that contains 30% of total calories as fat with one that contains 40%, then the picture gets complicated, because both diets are already so high in fat, the difference is negligible. And, of course, if you add in smoking, that can complicate the picture even more. But when you compare radically low-fat diets with the much higher fat intake of the average American, then you see the difference.

- Bill
(Edited by William Dwyer on 3/13, 12:53am)


Post 34

Thursday, March 13, 2008 - 4:12amSanction this postReply
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Bill,

========
Why does the buildup of plaque narrow the arteries of Americans, greatly reducing blood flow to their hearts and forming blood clots that partially or totally block their coronary arteries, when this sort of thing doesn't happen to the Masai? Why do Americans get heart attacks from atherosclerosis, when the Masai do not?
========

It's because inflammation and hemostasis are more important than atherosclerosis in outcome. Masai don't eat an inflammatory, blood-sludging diet like the AHA Step 1 diet. When the AHA Step 1 diet was compared to the Mediterranean diet, it caused twice the death (even though it was lower in fat). That study, the Lyon Heart study, was stopped early because the investigators felt it immoral to let folks continue on the low-fat death-diet which had been approved by the low-fat doctors. References available.


========
So, you're saying that extensive atherosclerosis and the narrowing of the coronary arteries isn't due in most cases to a high-saturated fat intake?
========

No, what I'm saying is that high saturated fat intake doesn't cause atherosclerosis without "help" from the rest of the standard American (read: anti-evolutionary) diet.


========
The question I would ask is, what diets are they comparing? because very low fat diets (with 10% of total calories as fat) in indigenous populations like the Indians of Northern Mexico and certain African tribes indicate zero heart disease and correlate with very low total serum cholesterol between 110 and 130 mg/dL, while rampant heart disease in Western first-world countries is correlated with diets that are much higher in fat.
========

First off, very high fat diets (Inuit) also indicate zero heart disease (and even low blood cholesterol), so your point isn't strong. Here's a study on high fat diets versus really low fat diets ...


========
Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2007 Mar 7;297(9):969-77.

" ... MAIN OUTCOME MEASURES: Weight loss at 12 months was the primary outcome. Secondary outcomes included lipid profile (low-density lipoprotein, high-density lipoprotein, and non-high-density lipoprotein cholesterol, and triglyceride levels), percentage of body fat, waist-hip ratio, fasting insulin and glucose levels, and blood pressure. ...

... RESULTS: Weight loss was greater for women in the Atkins diet group compared with the other diet groups at 12 months ...

... Weight loss was not statistically different among the Zone, LEARN, and Ornish groups. At 12 months, secondary outcomes for the Atkins group were comparable with or more favorable than the other diet groups. ... "
========

And that's pretty good evidence -- damn good evidence, actually -- for the UNconventional view.

;-)

Ed

Post 35

Thursday, March 13, 2008 - 5:07amSanction this postReply
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This is like watching a battle between Quaker Oats and Wheaties.......;-)

Post 36

Thursday, March 13, 2008 - 7:48amSanction this postReply
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Michael,

What you are describing is called calorie restriction or CR. It usually requires a difficult 30% reduction (rather than 5-10%), and it's benefits might be achieved easier by carbohydrate reduction alone.

References upon request.

Ed


No need, I am very familiar with Caloric Restriction diets and have actually communicated a few times with Dr. Richard Weindrich who was heading up the Wisoncon Primate Research centers CR tests on Chimpanzee's. About ten years ago most adherents to CR started moving to referring to CR as CRON, or, 'Caloric Restriction with Optimal Nutrition' to differentiate themselves clearly from mere starvation.

For Caloric Restriction to have any significant difference on maximum potential life span, a 30% or so reduction is needed, but a *moderate* reduction of 5-10%, while effecting maximum potential life span very little, affects average potential life span tremendously, virtually every health benefit imaginable is achieved through even mild to moderate CRON diets.

I've never come across evidence showing that carbohydrate reduction alone achieves this and I am skeptical given the complex mechanism by which CRON is thought currently to work, but if that is so, either diet would seemingly incur greater health benefits than the diet you are proposing.

Post 37

Thursday, March 13, 2008 - 11:28amSanction this postReply
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Rev',

That's funny. Do you yet know about the litigious history of the Kellogg's brothers (as in Corn Flakes)?

Ed

Post 38

Thursday, March 13, 2008 - 11:35amSanction this postReply
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Michael,

The diet I'm proposing -- the diet Nature is proposing (I like to say that) -- is a very low glycemic load diet. There isn't any direct evidence that CRON is any better than this diet that I'm proposing, although I'll be keeping my eyes open on the evidence horizon with a newly-found zeal.

Thanks for making that bold conjecture that CRON is better. I can understand why you would say such a thing (with boatloads of empirical evidence backing it).

Ed

Post 39

Thursday, March 13, 2008 - 2:21pmSanction this postReply
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Here's a few cool reports ...

========
Lifespan and reproduction in Drosophila: New insights from nutritional geometry. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2498-503

" ... Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein-carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. ... "
========
Recap:
In flies, protein-to-carb ratios are at least as important -- if not, more important -- than restricting calories.



========
Caloric restriction mimetics: the next phase. Ann N Y Acad Sci. 2005 Dec;1057:365-71.

"Calorie restriction (CR) mimetics are agents or strategies that can mimic the beneficial health-promoting and anti-aging effects of CR ...

... Our lead compound, developed at the National Institute on Aging, was 2-deoxyglucose, an analogue of the native sugar, that acted as a glycolytic inhibitor, having limited metabolism and actually reducing overall energy flow--analogous to CR. This agent reduced insulin levels and body temperature of rats, similar to the physiological effects of CR, but toxicity was noted in long-term studies, which apparently prevented life-span extension.

We previously demonstrated that lower insulin and body temperature (as well as maintenance of dehydroepiandrosterone levels) correlate with longevity in non-CR humans. The recent work of other investigators shows that humans subjected to short-term CR also have lower insulin and body temperature. Obviously, longer-term CR is extremely difficult to maintain; hence, the need for CR mimetics. ... "
========
Recap:
Insulin (which, by the way, is controlled most by the protein-to-carb ratio) and the weak androgenic hormone, DHEA, are at least as important -- if not, more important, than restricting calories.


========
Dietary composition affects regional body fat distribution and levels of dehydroepiandrosterone sulphate (DHEAS) in post-menopausal women with Type 2 diabetes. Eur J Clin Nutr. 1999 Sep;53(9):700-5.

" ... After adjustment for age, dehydroepiandrosterone sulphate (DHEAS) concentrations after the high-CHO diet were related to levels of lower body fat (r = 0.394, P = 0.04). CONCLUSIONS: In women with Type 2 diabetes following a high-CHO diet for 12 weeks the disproportionate loss of lower body fat is related to a decline in DHEAS."

========
Recap:
In middle-aged gals with diabetes, higher carb intake led to reduced DHEA levels.


Recap on the recaps:
Consuming more than twice the carb grams as protein grams -- will likely reduce your "healthspan" (years of healthy life) -- by increasing your insulin and lowering your DHEA.

Ed
[edited twice; 5 minutes and 10 minutes after initial posting]
(Edited by Ed Thompson on 3/13, 2:43pm)


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